To all wxPython users: use XRCed. It's unpolished, but the day spent learning it pays off quickly. Unlike drag and drop GUI editors, XRCed uses sizers. You get a UI that scales with font sizes, without the surprisingly difficult work of constructing GUIs in code. XRC files are easy to load in Python code. Also, XRC nearly eliminates those pesky integer window identifiers.

Start with the XRCed tutorial by Dimitri Pater.

(I admit this post has an alterior motive: if more people use XRCed and XRC files, both XRCed and the methods of using XRC files in wxPython will improve.)